Organ failure is not acceptable as the underlying cause of death. Organ failure - such a heart, renal or liver failure - can be caused by many different conditions that may have different prevention interventions. If possible, enter the disease that caused the organ failure.  Heart failure, for example, could be caused by numerous conditions, such as rheumatic heart disease - which would require antibiotic treatment for streptococcal infections - or ischaemic heart disease - which would require lifestyle interventions and treatment to manage hypertension.